ESR1 and ESR2 gene polymorphisms are associated with human reproduction outcomes in Brazilian women
نویسندگان
چکیده
منابع مشابه
ESR1 and ESR2 gene polymorphisms are associated with human reproduction outcomes in Brazilian women
BACKGROUND Important candidate genes involved in the ovarian response to exogenous FSH are the estrogen receptor genes (ESRs), since the effects of estrogens on follicle growth, maturation and oocyte release. It is known that some markers of ovarian stimulation can help to personalize the treatment, adjusting the dose of exogenous rFSH, thus preventing excessive wear of the patient. Inspired on...
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CONTEXT Hypospadias is a common congenital malformation of the male external genitalia with a multifactorial etiology. Little is known about the genes involved in hypospadias. A few genetic associations have been reported but mainly in studies of small sample size. Most of these associations have not been replicated. OBJECTIVE The aim of this study was to investigate whether previously report...
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CONTEXT Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results. OBJECTIVE To generate large-scale evidence on whether 3 common ESR1 polymorphisms (intron 1...
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ژورنال
عنوان ژورنال: Journal of Ovarian Research
سال: 2014
ISSN: 1757-2215
DOI: 10.1186/s13048-014-0114-2